Democracia para quem não acredita

Divulgação dos SUMÁRIOS das obras recentemente incorporadas ao acervo da Biblioteca Ministro Oscar Saraiva do STJ. Em respeito à Lei de Direitos Autorais, não disponibilizamos a obra na íntegra.Localização na estante: 321.7 A134

O processo civilizador e os direitos fundamentais * The civilizing process and fundamental rights

O artigo destaca a importância da formulação teórica de processo civilizador elaborada por Norbert Elias para se compreender corretamente o conceito de direitos fundamentais. Trata-se de uma forma de visualizar esses direitos que permite a superação da defesa da dicotomia estabelecida entre jusnaturalismo e positivismo.

DO GENUÍNO PRECEDENTE DO STARE DECISIS AO PRECEDENTE BRASILEIRO: OS FATORES HISTÓRICO, HERMENÊUTICO E DEMOCRÁTICO QUE OS DIFERENCIAM

Trata-se de artigo cuja finalidade é exclusivamente comparativa. O escopo é demonstrar que não devemos confundir o sistema de provimentos vinculantes do CPC-2015 com o sistema genuíno de precedentes do direito inglês. Essa diferenciação busca evitar sincretismos e permitir uma aplicação mais adequada do CPC-2105 aos princípios constitucionais

Constituição federal comentada

Divulgação dos SUMÁRIOS das obras recentemente incorporadas ao acervo da Biblioteca Ministro Oscar Saraiva do STJ. Em respeito à Lei de Direitos Autorais, não disponibilizamos a obra na íntegra.Localização na estante: 342.4(81)"1988" Coment. A134

Direito constitucional pós-moderno

- Divulgação dos SUMÁRIOS das obras recentemente incorporadas ao acervo da Biblioteca Ministro Oscar Saraiva do STJ. Em respeito à Lei de Direitos Autorais, não disponibilizamos a obra na íntegra.- Localização na estante: 342 A134

Maxillary sinus augmentation by the crestal approach: radiographic changes in graft height. A 1-year retrospective study

The purpose of this study is to evaluate, radiographically, the change in intra-sinus graft height after implant placement using inorganic mineral bovine bone and the osteotome technique. Thirty-one implants were placed in twenty-five patients with simultaneous sinus lift using the crestal approach and deproteinized bovine bone ((Bio-Oss®). Periapical radiographs were taken immediately after implant placement, after six months (healing period), and after a minimum of six months of loading. Changes of the graft height were evaluated using image analysis software (Image Tool for Windows, version 3, UTHSCA). The distance between the implant apex and the graft summit was measured along the longitudinal axis of the implant (distance D). This distance was consecutively measured on radiographs taken immediately after surgery (D0), at second stage surgery (D6), and at follow-up visits (D12). Only 25 out of 31 implants were included to analyze the variation in the distance D in time (D6 and D12). Statistical analysis showed a significant difference between D0 and D6 (p\u3c0.0001), between D6 and D12 (p\u3c0.002), and between D0 and D12 (p\u3c0.001). The graft lost 27.4% of its apical height after twelve months. Within the limitations of the present study it was found that the use of deproteinized bovine bone, which has a very slow resorption rate, could not prevent changes in the initially gained intrasinus graft height. However, the reported results showed that its use was beneficial in limiting the loss of the augmented height to a minimum

Inhibition of Glycolysis Reduces Disease Severity in an Autoimmune Model of Rheumatoid Arthritis.

The K/BxN mouse is a spontaneous model of arthritis driven by T cell receptor transgenic CD4+ T cells from the KRN strain that are activated by glucose-6-phosphate isomerase (GPI) peptides presented by the H-2g7 allele from the NOD strain. It is a model of autoimmune seropositive arthritis because the production of anti-GPI IgG is necessary and sufficient for joint pathology. The production of high levels of anti-GPI IgG requires on the expansion of CD4+ follicular helper T (Tfh) cells. The metabolic requirements of this expansion have never been characterized. Based on the therapeutic effects of the combination of metformin and 2-deoxyglucose (2DG) in lupus models that normalized the expansion of effector CD4+ T cells. We showed that the CD4+ T cells and to a lesser extent, the B cells from K/BxN mice are more metabolically active than the KRN controls. Accordingly, preventive inhibition of glycolysis with 2DG significantly reduced joint inflammation and the activation of both adaptive and innate immune cells, as well as the production of pathogenic autoantibodies. However, contrary to the lupus-prone mice, the addition of metformin had little beneficial effect, suggesting that glycolysis is the major driver of immune activation in this model. We propose that K/BxN mice are another model in which autoreactive Tfh cells are highly glycolytic and that their function can be limited by inhibiting glucose metabolism

Repetitivos ou "ineditivos"?: sistematização do recurso especial repetitivo

- Divulgação dos SUMÁRIOS das obras recentemente incorporadas ao acervo da Biblioteca Ministro Oscar Saraiva do STJ. Em respeito à Lei de Direitos Autorais, não disponibilizamos a obra na íntegra.- Localização na estante: 347.955(81) G643re- Coordenado por: Luiz Rodrigues Wambier, Fabio L. Quintas e Georges Abbou

Introdução ao direito: teoria, filosofia e sociologia do direito

Divulgação dos SUMÁRIOS das obras recentemente incorporadas ao acervo da Biblioteca Ministro Oscar Saraiva do STJ. Em respeito à Lei de Direitos Autorais, não disponibilizamos a obra na íntegra.Localização na estante: 34.01 A134

Immune Response-Dependent Assembly of IMP Dehydrogenase Filaments

Inosine monophosphate dehydrogenase (IMPDH) catalyzes the conversion of IMP to xanthosine monophosphate, the rate-limiting step in de novo guanosine monophosphate (GMP) synthesis. In cultured cells, IMPDH polymerizes into micron-scale filamentous structures when GMP synthesis is inhibited by depletion of purine precursors or by various drugs, including mycophenolic acid, ribavirin, and methotrexate. IMPDH filaments also spontaneously form in undifferentiated mouse embryonic stem cells and induced pluripotent stem cells, hinting they might function in various highly proliferative cell types. Therefore, we investigated IMPDH filament formation in human and murine T cells, which rely heavily on de novo guanine nucleotide synthesis to rapidly proliferate in response to antigenic challenge. We discovered extensive in vivo IMPDH filament formation in mature T cells, B cells, and other proliferating splenocytes of normal, adult B6 mice. Both cortical and medullary thymocytes in young and old mice also showed considerable assembly of IMPDH filaments. We then stimulated primary human peripheral blood mononuclear cells ex vivo with T cell mitogens phytohemagglutinin (PHA), concanavalin A (ConA), or antibodies to CD3 and CD28 for 72 h. We detected IMPDH filaments in 40–60% of T cells after activation compared to 0–10% of unstimulated T cells. Staining of activated T cells for the proliferation marker Ki-67 also showed an association between IMPDH filament formation and proliferation. Additionally, we transferred ovalbumin-specific CD4+ T cells from B6.OT-II mice into B6.Ly5a recipient mice, challenged these mice with ovalbumin, and harvested spleens 6 days later. In these spleens, we identified abundant IMPDH filaments in transferred T cells by immunofluorescence, indicating that IMPDH also polymerizes during in vivo antigen-specific T cell activation. Overall, our data indicate that IMPDH filament formation is a novel aspect of T cell activation and proliferation, and that filaments might be useful morphological markers for T cell activation. The data also suggest that in vivo IMPDH filament formation could be occurring in a variety of proliferating cell types throughout the body. We propose that T cell activation will be a valuable model for future experiments probing the molecular mechanisms that drive IMPDH polymerization, as well as how IMPDH filament formation affects cell function